The Southeast Regional Collaborative Access Team (SER-CAT) is an organization consisting of 22 Member and 5 Associate User institutions, formed in 1997 to provide third generation x-ray capabilities to macromolecular crystallographers and structural biologists in the southeastern region of the U.S. 

Emphasis is placed on de novo SAD/MAD structure determination, high-resolution structural analyses, large unit cells, drug design, structural genomics, soft X-ray data collection and next-generation beamline automation. SER-CAT is located at the Advanced Photon Source, Argonne National Laboratory, and is operated by the University of Georgia, with  Professor Bi-Cheng Wang as Director.

Please peruse the pages of our website to find out more about SER-CAT and how we are "shining a new light" on protein crystallography.  Have a look at The SER-CAT Spectrum, our newsletter, to learn about recent breakthroughs.  As always, your comments and suggestions are welcome. 

Thank you for visiting! 


*News and Announcements*

General Information


15th Annual SER-CAT Symposium



The 15th Annual SER-CAT Symposium will be held on Friday April 13, 2018 at the Georgia Institute of Technology. The Annual Board Meeting will be held on Saturday, April 14.

SER-CAT Detector Workshop

A workshop on the "Best Practices for the Collection, Processing, Analysis, Transfer & Storage of data from the new Eiger 16M detector" will be held on April 12th preceeding the SER-CAT  Symposium.  The workshop is free for SER-CAT Symposium registrants.

Link to the Symposium web site

Link to the Detector Workshop Information

14th Annual SER-CAT Symposium 


April 17, Scripps - Florida  (enlarged photo)

The 14th Annual SER-CAT Symposium was held on April 7, 2017 on the Scripps Research Institute – Florida Campus. The meeting featured talks related to the APS upgrade, highlights of scientific advances enabled by SER-CAT data, new user tools available at SER-CAT and the presentation SER-CAT Young Investigator and Outstanding Awards. A posted session followed.

Dr. Stephen Streiffer, the ANL Associate Laboratory Director for Photon Sciences presented current plans for upcoming APS upgrade followed a discussion with the meeting participants on the upgrade will impact SER-CAT capabilities and support new science.

Meeting participants discussed outstanding research projects conducted at SER-CAT throughout the year. SER-CAT beamline scientists shared the beamline advances including new sector specific hardware and software, and data collection features. SER-CAT director Dr. Bi-Cheng Wang presented the “SER-CAT Pilot Project: Phase II – Extending the concept of color photography to routine chromatic X-ray Crystallography”.

SER-CAT sincerely thanks the Symposium's organizing committee Dr. Tina Izard, Ms. Candace Morrow and the staff at the Scripps Research Institute – Florida Campus for planning and organizing this year's informative and very enjoyable event. Our sincere thanks to all speakers and participants for making this year's symposium such a successful event.


SER-CAT 2017 Award Winners


The 2017 SER-CAT Outstanding Science Award was presented to Dr. Jochen Zimmer (boxed), University of Virginia for his work on "Observing cellulose biosynthesis and membrane translocation in crystallo”. Since Dr. Zimmer could not attend the Symposium, the Award was received from Dr. B.C. Wang by Dr. Owen Pornillos, the SER-CAT Board member form Virginia.


The 2017 SER-CAT Young Investigator Award was presented to Mr. William Bradley O’Dell, North Carolina State University, by Dr. B.C. Wang for his researchon “Oxygen activation by a lytic polysaccharide monooxygenase”.

Special thanks to all of the nominators for this year's Awards.

Previous Award Winners

Click here for a list of previous SER-CAT Award Winners


Award Nomination Packets Available

2018 SER-CAT Outstanding Science Award

2018 SER-CAT Young Investigator Award


The SER-CAT Approach!

We would like to share a slide presentation given by SER-CAT Director Dr. Bi-Cheng Wang at the 9th International Conference on Biology and Synchrotron Radiation in Manchester, England, entitled, "Remaining Challenges in Long Wavelength Phasing: The SER-CAT Approach" (PDF). This presentation highlights SER-CAT's work on data collection at all possible wavelengths, including sulfur phasing.


SER-CAT Featured on  World Business Review


SER-CAT was featured on the TV program World Business Review, which aired on the Bravo Network in February 2005. You may view the featured segment in streaming audio following the links below. 


Windows Media video (300K)

Real Player video (300K)

If you would like a copy of this video to distribute locally on CD or DVD, please contact Lily Li at


As a service to our Members, SER-CAT is pleased to provide helpful links for the following information:

Lease and/or Sale Opportunities Available by Members


Positions Available at SER-CAT and/or Member Institutions


Other Membership Announcements



Associate User Memberships Available


Associate User memberships are now available on a yearly basis with no capital; investment or long-term contractual commitment. Associate memberships are available to both academic and industrial users and provide full access to SER-CAT's outstanding Remote Access program at an attractive cost.


For more information, please contact SER-CAT Program Coordinator, Ms. Zhi-Qui (Lily) Li at

Link to the Associate User Flyer

Eiger 16M Detector Installed on 22ID

The new Dectris Eiger 16M detector has been commissioned at 50 Hz and is available to users on beamline 22ID. The Eiger is a hybrid photon counter that has a pixel size comparable to that of the Rayonix MX300HS but can collect data up to ten times faster (100 Hz). In addition, unlike the MX300HS, the Eiger has a very high dynamic range reducing saturation problems. When coupled with the new KB mirrors being installed on 22ID the beamline should be ideal for microcrystallography. The Rayonix MX300HS detector will be moved to beamline 22BM significantly increasing data rate and data quality. 

A workshop on "Best Practices for the Collection, Processing, Analysis, Transfer and Storage of Data from the New SER-CAT Eiger 16M Detector" will be offered on April 12, 2018 (one day before the SER-CAT Symposium) at the Georgia Institute of Technology.

Link for the detector Workshop Infromation

 Staffing Changes

SER-CAT welcomes Dr. Norma Duke who will be replacing Gina Ranieri in April. Dr. Duke joins us from SBC CAT where she was a Beamline support Specialist/Macromolecular Crystallographer.  She will assume most of Gina's duties, as well as  provide User Support.

SER-CAT welcomes Michael Molitsky, Mike as SER-CAT Senior Beamline Engineer will assume John Gonczy’s duties related to beamline matters.  Mike was the Principal Beamline Scientist at SBC-CAT from 2004 to 2016 and also was responsible for optic and hardware improvements.

SER-CAT welcomes Lily Li and Jackie Taylor who will be joining the  Administrative Office at UGA. Lily has been with us since 1996 and has been promoted to SER-CAT Program Coordinator where she will assume the most of Kathy Savage's outreach and administrative duties while Jackie will serve as the SER-CAT Administrative Specialist assuming Kathy's accounting duties.

SER-CAT bids a fond farewell to John Gonczy, Kathy Savage and Gina Ranieri. John was part of the SER-CAT construction team and served as Beamline Engineer and User Support since 2002. He has retired after 20 years service. Kathy has served as the SER-CAT Administrative Coordinator and played an important role in the establishment, and success of SER-CAT. She is retiring after 30 years' service to UGA. Gina our User Support Coordinator has left us to pursue a career at Procter & Gamble. SER-CAT wishes Gina all success in her new career.

Rayonix MX300HS Users Guide

A data collection guide for the MX300HS has been prepared and can downloaded by clicking the link below.

Link for the MX300HS Users Guide

Please look it over since there are several changes in what you will need to do to collect data and process data with the new detector.

HKL2000 for the MX300HS

A new version of HKL2000 that can process the data from the MX300HS detector is available for download from HKL Research.  Please contact them for download instructions.  You will alos need to get an updated cr_info file.

SER-CAT Automounters 

Both BM and ID Robots are fully commissioned. All first time robotics users must contact Norma Duke (SER-CAT's User Support Coordinator) prior to their visit.

The ALS Style magnetic caps are available from Hampton Research, P/N HR4-779

The 18mm Mounted litholoops are available from Molecular Dimensions.

The dry shipping dewars compatible with SER-CAT puck holder are from Taylor-Wharton (Model: CX100 or CXR100). The product vendor is:

SER-CAT's robotic pucks, puck holder and tools are available from the University of Georgia Instrument Shop, 955 East Whitehall Rd., Athens, GA 30602. Please Contact Mr. Lewis Fortner via e-mail ( or  Fax (706-542-7921) for pricing and availability.

Firewire Disk Drives

Users should avoid using Firewire disk drives having a metal case for data backup at SER-CAT.  The long data backup causes metal cased drives to over heat redulting in drive failure


SER-CAT'S 20th Anniversary
2017 marks SER-CAT's 20th year of operation. We have put together a slide show (below) highlighting SER-CAT's early history which B.C. Wang presented at the Scripps-Flordia SER-CAT Symposium.

SER-CAT: The first 10 years
SER-CAT celebrated its 10th year Anniversary in 2007. In honor of this special occasion, SER-CAT's director Dr. Bi-Cheng Wang created a historical presentation highlighting many SER-CAT's exciting achievements. You are invited to view this PDF slideshow entitled, "SER-CAT: The First 10 Years" to see the chronological history of our development, including the important ribbon cutting ceremony held at the APS in 2002. We sincerely express our gratitude to each of you who supported SER-CAT's growth, and look forward to many more productive years ahead!

The Beamline dedication ceremony in Argonne, IL

Celebrating the official opening of SER-CAT's 1st beamline, October 2002, APS, ANL

   Photo of the Advanced Photon Source in Argonne, IL.